ABSTRACT
Aim: The contagious disease COVID 19 is a recently out-broken pandemic situation which threatens humankind all over the world. Siddha system of medicine is one of the traditional medical systems of India, which has provided a novel remedy for many epidemics like Dengue, Chicken guinea earlier. On evaluating the literature evidence and considering the mortality and severity of the disease, we have attempted to identify the possible inhibition of viral replication by "Karisalai Chooranam" - a polyherbal Siddha formulation which contains herbs like Karisalai (Wedelia chinensis), Thoodhuvelai (Solanum trilobatum), Musumusukai (Melothria maderaspatana) and Seeragam (Cuminum cyminum). The aim of this study was to identify the bioactive components present in Karisalai chooranam and pin down the components that inhibit COVID 19 protease by In Silico molecular docking analysis. Material and methods: The study was performed for the active compounds present in the herbs (Wedelia chinensis - Benzoic acid, Solanum trilobatum- Disogenin, Melothria maderaspatana- beta-sitosterol, Cuminum cyminum L- Coumaric acid and Limonene) with three potential targets, PDB id: 6LU7 3-chymotrypsin-like protease (3CLpro), PDB id: 6-NUR RNA dependent RNA polymerase and PDB id: 2AJF Angiotensin-converting enzyme II (ACE2) receptor using Autodock Vina. Key findings: The active phytocomponents present in "Karisalai chooranam" was found to inhibit the target 3CL proenzyme and hereby halt the formation of 16 non-structural proteins (nsp1-nsp16) that are highly essential for viral replication and there by prevents viral survival in the host environment. The phytocomponents also inhibited the target RNA dependent RNA polymerase (PDB)-6NUR RdRp which possess versatile action in mediating nonstructural protein (nsp 12) essential for viral replication. A significant binding against the target Angiotensin-converting enzyme II (ACE2) receptors - PDB- 2AJF was found which was recognized as a binding site for novel coronavirus to cause its pathogenesis. Among the five active components present in the herb, the binding ability of Disogenin and beta-sitosterol with COVID19 protease suggests a possible mechanism of protease inhibition and thus preventing viral replication. Significance: The results strongly suggest that phytocomponents of "Karisalai chooranam" may act as a potential therapeutic agent for the management of COVID-19 and related symptoms. Further, the efficacy of the active compounds should be tested in vitro before being recommended as a drug.
ABSTRACT
Increasing body immunity is very necessary after the Covid-19 pandemic. One of the efforts that can be made to increase the body's immunity is to consume functional foods with immunostimulant activity, such as processed snakehead fish products in the form of nuggets, and "parkusel" juice made from a mixture of bitter melon, dates and celery. The purpose of community service is to provide knowledge and skills to housewives and the community at the Veteran ABRI Housing Complex in Medan Estate, Deli Serdang Regency, in making functional food products in the form of snakehead fish nuggets and Perkusel juice. The community service method used is the counseling method with leafet aids and training in making snakehead fish nuggets and perkusel juice. The results of the activity showed that there was an increase in the knowledge of the community participants in community service activities about nutritious snack products that can increase body immunity by 71% in the good value category.
ABSTRACT
Covid-19 pandemic had limited people's movement despite the demand to remain productive and maintain good health. Therefore, it was necessary to provide foods which are easy to distribute, durable, nutritious, and easily transformable to increase immunity. This research aims to develop a composite flour (TK) formula with optimal proportion of wheat flour (TT), snakehead fish flour (TIG), pumpkin flour (TBuL), and pumpkin seed flour (TBiL) which then enriched with zinc. The resulting TK is expected to be used as an ingredient for nutritious snacks containing high protein and zinc. The research was conducted in four stages, namely the making of each constituent flour, determining the best formulation with the Response Surface Methodology using Central Composite Design model, characterizing the physicochemical properties of TK and making meatballs, biscuits, and unting-unting from the TK. The three products were tested on experimental animals for their metabolic responses. The optimization of the formula resulted in three optimal formulations, namely formula A, B, and C with the proportion of TT:TIG:TBuL:TBiL respectively as follows 55:20:15:10;56.65:20:13.35:10;57.98:20:12.02:10. The most optimal formula of composite flour was formula A with the highest protein (26.12%) and zinc (18.06 mg/kg) content among other formulas. Then, zinc was added into Formula A using microencapsulation, and TK with protein content of 26.74% and zinc of 56.8 mg/kg were obtained. The histopatology observation on experimental animals showed that the three products made from TK did not cause necrosis of the liver or cell infiltration in the kidneys.
ABSTRACT
Purpose: Childhood obesity has become a social problem due to the social distancing necessitated by the coronavirus disease 2019 pandemic. This study aimed to identify the dietary problems of obese children through various dietary assessment methods and to confirm the usefulness of each method. Methods: The subjects were 88 students in the 4th to 6th grade of elementary school who participated in the nutrition camp organised by the Busan Metropolitan Office of Education, 2020. To evaluate dietary problems and assess diet quality, 24-hour meal records, monthly food intake frequency, and Dietary Screening Test (DST) data were analyzed. Results: Of the subjects, 15.7%, 30.3%, and 53.9% were normal weight, overweight, and obese, respectively. The average age was 11.77 +or- 0.77 years and the average body mass index was 23.96 +or- 3.01 kg/m2. It was observed from the 24-hour meal record method that the overweight and obese subject groups consumed fewer green vegetables (p < 0.001) and white vegetables (p < 0.01) than the normal weight group. In the monthly food intake frequency method, the consumption of ramen (p < 0.01), snacks (p < 0.05), and sausages (p < 0.05) were high in the obese group, and that of anchovies, broccoli, and sweet pumpkin was high in the normal group (p < 0.05). The comparative data from the DST revealed that the overweight and obese groups had less vegetable intake than the normal weight group (p < 0.01) and had higher intakes of dairy products, fast food, and sweet snacks (p < 0.05). Conclusion: The usefulness of each method in the dietary evaluation of obese children was confirmed. To address the problem of obesity, it is necessary to evaluate the dietary problem and approach it with a customized solution tailor-made for the individual subject.
ABSTRACT
The Covid-19 pandemic has greatly affected people's lives, especially women farmer from the Sibermas Mandiri Women's Farmer Group, Pudak Village, Kumpeh Ulu District, Muarojambi Regency. This pandemic has resulted in a decline in household income. Therefore, it is necessary to find a solution to increase their household income through the cultivation of Butternut Squash (Curcubita moschata) which currently has a large enough opportunity and market potential to become a business. In an effort to achieve this target, the Butternut Squash cultivation innovation can be implemented through the "Learning by Doing" model, which is a cultivation implementation model that is directly carried out by the Women Farmers group on the land. The result of these activities show that the average butternut squash production reaches +or- 150 kg. With the selling price of butternut squash Rp.8.000/kg, the average omzet obtained is +or- Rp. 1.200.000,-. It shows that the cultivation of butternut squash can increase household income and encourage the women farmer group to continue the cultivation of butternut squash independently.
ABSTRACT
In the Republic of Kazakhstan melons and gourds are produced mainly in the traditional way, that is, by using chemical fertilizers and pesticides. The production of environmentally friendly melons is at the initial stage of its development. There is no organic melon growing at all. Considering the huge export potential of melons among other crops cultivated in the country (the total supply of melons and melons on the domestic market is 472%), the great economic and social significance of the transition of the melon industry to organic production is growing. In the future, Kazakhstan may be in the center of attention of the world community as a manufacturer and supplier of environmentally friendly (organic) melons, and environmentally friendly, natural melons may well become a brand of our sovereign state. To do this, it is necessary to make fundamental changes in the melon industry of the country. In general, the transition of agricultural production to an organic direction will contribute to the consumption of the safest and most useful products by the local population. Here, one should also take into account the decrease in the immunity of the human body due to various diseases, including those associated with the coronavirus pandemic. It should also be taken into account that only a limited number of pesticides used against harmful objects in agriculture act as intended, and most of the toxic substances spread into the environment. The use of disinfectants without scientific support has a negative impact on flora and fauna, being deposited in the soil and irrigation system of fields for a long time, thereby causing enormous damage to the environment. Given the above facts, our scientific research was aimed at the selection of pesticides and biological preparations with high biological and economic efficiency, low rates and frequency of treatments, as well as varieties with high resistance to fungal diseases of melons (watermelon, melon). Research work was carried out on the experimental plots of the Regional Branch "Kainar" of the LLP "Kazakh Research Institute of Horticulture" in the period 2020-2021. The studies used classical methods generally accepted in melon growing. The results obtained are new and relevant, and in the future, will contribute to the transition from traditional melon growing to biological.
ABSTRACT
The COVID-19 pandemic presented many challenges for the LSU AgCenter 4-H program. To meet social distancing guidelines and ensure the safety of youth and agents, many of programming efforts transitioned to a virtual format. However, the need remained for hands-on learning opportunities. 4-H programming is driven by the motto "learn by doing", and it was paramount that agents provide purposeful and engaging activities. The 4-H Seed-of-the-Month Club is a project club that emerged to meet that need. Agents created a nine-month seed subscription made available to youth across the region beginning in August 2020. With this project, participating youth were provided seeds of various plants, including pine seedlings, rainbow carrots, easter egg radishes, lettuce, green beans, okra, squash and coneflowers. Agents used the LSU AgCenter Louisiana planting guide to select the seeds to offer each month. In the future, agents and youth alike have expressed an interest in continuing to provide horticulture opportunities through the delivery mode of the Seed-of-the-Month Club. Participants were asked to provide top choices for their gardens by receiving carrots, lettuce and green bean seeds for the future.
ABSTRACT
The audience of consumers of watermelon and melon is the widest, the reason for this is the light and at the same time rich composition of sweet fruits. Given the increase in complications among the country's population associated with the postponed coronavirus pandemic, the consumption of highly vitaminized and environmentally friendly products is especially important. Unfortunately, in recent years there has been an acute issue of unfair production of melons and gourds. In pursuit of an early harvest, producers completely forget about quality. Melon products contaminated with nitrates can lead to the most serious consequences. The way out of this situation is to use biological stimulants of the vital activity of soil microorganisms, which accelerates the maturation processes, while reducing the introduction of agrochemicals by almost twice. According to the results of our research, it was found that the treatment of plants with biological stimulants increased the yield of watermelon by 33.88%, melon -27.30%. Plants treated with bio stimulants were larger, had a greater number of ovaries to control, respectively. Biochemical analysis showed an increase in dry matter, total sugar and ascorbic acid in the fruits of watermelon and melon.
ABSTRACT
During the COVID-19 pandemic, customer awareness for food quality and safety is distinctly higher. Fresh-cut fruits in Indonesia are traditionally distributed using wheelbarrows. The increasing consumption of fruit in Indonesia must be accompanied by awareness of healthy lifestyles and the shift of consumer behavior to online stores. The purpose of this study was to determine the effect of storage methods and packaging materials for fresh-cut melon on changes in physicochemical properties during the distribution process. Variation of packaging materials used were polypropylene, plastic wrap, and without packaging as control. The ice gel in cooled box delivery was used for storage method during distribution and compared to conventional methods (manual fruit carts). The physical parameters of melons fruit observed during distribution were weight loss, hardness level, pH value, and total soluble solids (TSS). The fresh-cut melons were stored in a distribution box which kept the temperature at +or- 18 degrees C for 6 h. The results showed that the storage method had a significant effect (p < 0.05) on all parameters of physical quality. While packaging material had a real effect (p < 0.05) on weight loss and TSS, but has no effect (p < 0.05) on hardness level and pH value. Packaging using plastic wrap can reduce the weight loss of fresh-cut melons, while polypropylene plastic can maintain the hardness level, pH value, and TSS of cut melons fruit.